There has been alot of hype and talk about Phentermine as the bes diet pill in the market. However, before taking the drug, it is important to understand some basic facts.

History of Phentermine -
In 1959 phentermine first received approval from the FDA as an appetite suppressing drug. Phentermine hydrochloride then became available in the early 1970s. It was previously sold as Fastin from King Pharmaceuticals for SmithKline Beecham, however in 1998 it was removed from the market. Medeva Pharmaceuticals sells the name brand of phentermine called Ionamin and Gate Pharmaceuticals sells it as Adipex-P. Phentermine is also currently sold as a generic. Since the drug was approved in 1959 there have been almost no clinical studies performed. The most recent study was in 1990 which combined phentermine with fenfluramine or dexfenfluramine and became known as Fen-Phen.

In 1997 after 24 cases of heart valve disease in Fen-Phen users, fenfluramine and dexfenfluramine were voluntarily taken off the market at the request of the FDA. Studies later proved that nearly 30% of people taking fenfluramine or dexfenfluramine had abnormal valve findings. The FDA did not ask manufacturers to remove phentermine from the market.

Phentermine is still available by itself in most countries, including the U.S. However, because it is similar to amphetamines, it is classified as a controlled substance in many countries. Internationally, phentermine is a schedule IV drug under the Convention on Psychotropic Substances. In the United States, it is classified as a Schedule IV controlled substance under the Controlled Substances Act.

What is phentermine?
Phentermine is a class of drugs called anorectics which decrease appetite by possibly changing brain levels of neurotransmitters associated with satiety. Phentermine is a stimulant that is similar to an amphetamine

• Phentermine Hydrochloride Oral tablet come in different commercial trade names:
  Adipex P (Immediate release)
  Anoxine-AM
  Ionamin (Slow Release Resin, Australia, discontinued in the US)
  Duromine (Slow Release Resin, New Zealand, Australia & South Africa)
  Fastin
  Mirapront
  Obephen
  Obermine
  Obestin-30
  Phentrol
  Phenterex
  Phentromin
  Pro-Fast SA
  Redusa
  Panbesy
  Phentermine Trenker
  Obenix
  Oby-Trim
  Teramine
  Zantryl
  Sinpet (MX)
  Supremin (PH)
  Umine (NZ)
  Weltmine (KP)

How does Phentermine work?
Phentermine stimulates nerves to release particular neurotransmitter called catecholamine. These include dopamine, epinephrine, (adrenaline) norepinephrine (noradrenaline). The increased levels of these chemicals appear to decrease the sense of hunger. Neurotransmitters are chemicals used to relay signal/messages in the brain.

These neurotransmitter eliminate the sense of hunger by putting your body in a small extent of “fight or flee’. This is the state your body takes when faced with danger. As you know if you see a car coming to hit you, you will not be aware of any hunger. Phentermine and other similar weight loss drugs like sibutramine and fenfluramine tend to mimic this state of “flight or flee” to some extent with their effect on neurotransmitters.

With the continued use of phentermine however, the effect of depressed appetite tend to wear off after a few weeks. This is why it is recommended for short term treatment. Some studies point to the possibility that this drug tolerance that results to reduced effect varies with individuals. One study has show phentermine to be still effective in a 3 year trial.

What is Phentermine used for?

It is a prescription weight loss pill that is used together with a Phentermine is used togther with diet and exercise to treat obesity (overweight) in people with risk factors such as high blood pressure, high cholesterol, or diabetes.

Phentermine may also be used for other purposes not listed in this medication guide.

What other information must I give my healthcare provider before taking Phentermine?

Taking phentermine together with other diet medications such as fenfluramine (Phen-Fen) or dexfenfluramine (Redux) can cause a rare fatal lung disorder called pulmonary hypertension. Do not take phentermine with any other diet medications without your doctor’s advice.

Do not take this medicine with any of the following medications:
•duloxetine
•MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
•medicines for colds or breathing difficulties like pseudoephedrine or phenylephrine
•procarbazine
•sibutramine
•SSRIs like citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline
•stimulants like dexmethylphenidate, methylphenidate or modafinil
•venlafaxine

This medicine may also interact with the following medications:
•medicines for diabetes

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Tell your healthcare provider if you have any of these conditions:
•agitation
•glaucoma
•heart disease
•high blood pressure
•history of substance abuse
•lung disease called Primary Pulmonary Hypertension (PPH)
•thyroid disease
•an unusual or allergic reaction to phentermine, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding
If you have any of these conditions, you may need a dose adjustment or special tests during treatment.

What are some side effects of Phentermine?

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
•chest pain, palpitations
•depression or severe changes in mood
•increased blood pressure
•irritability
•nervousness or restlessness
•severe dizziness
•shortness of breath
•problems urinating
•unusual swelling of the legs
•vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•blurred vision or other eye problems
•changes in sexual ability or desire
•constipation or diarrhea
•difficulty sleeping
•dry mouth or unpleasant taste
•headache
•nausea

Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may increase dizziness and drowsiness. Avoid alcoholic drinks.

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Other precautions:

You may have withdrawal symptoms, such as depression and extreme tiredness, when you stop using phentermine after a long period of use. Do not stop using phentermine suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

It is not known whether phentermine will harm an unborn baby. Do not take phentermine without telling your doctor if you are pregnant. It is also not known whether phentermine passes into breast milk or if it could harm a nursing baby. Do not take phentermine without telling your doctor if you are breast-feeding a baby. Do not give this medication to anyone younger than 16 years old without the advice of a doctor. Phentermine may be habit-forming and should be used only by the person it was prescribed for. Phentermine should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. This medicine is usually taken 30 minutes before or 1 to 2 hours after breakfast. Avoid taking this medicine in the evening. It may interfere with sleep. Take your doses at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Remember to buy drugs from reliable sources. It is not advisable to buy phentermine online without a prescription. Do not rely on the packaging or appearance of the pills, as you have no evidence that the pills contain the registered ingredients at the correct dosage and purity that is mandated by the marketing authorities. Problems with the quality of cheap phentermine ordered online and delivered to your doorstap overnight is more common than you think. You really do pay for what you get and many cases of fraud go undetected until death occurs. So better to be safe than sorry.

Technorati Tags: diet, exercise, health, weight loss

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It’s official, a low-carb diet is better at burning fat than just cutting calories.

American scientists who were working to find out how diet affects the operation of the liver put 14 overweight people on either a low carbohydrate or low calorie diet.

They found those eating fewer carbs lost almost double the weight over two weeks, and several changes in liver function were identified as part of the reason why.

“Energy production is expensive for the liver,” says Dr Jeffrey Browning, assistant professor at the UT Southwestern Medical Centre, in Dallas, Texas.

“It appears that for the people on a low-carbohydrate diet, in order to meet that expense, their livers have to burn excess fat.”

The average weight loss for the low-calorie dieters was about 2.2kg, while the low-carb dieters lost about 4.3kg on average.

Technorati Tags: diet, weight loss

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A report on “Booming Global Obesity Drug Market”, Research and Markets states that the prevalence of obesity is increasing globally at alarming rates. Obesity drugs market has shown a radical growth in recent times but in contrast, the market for weight loss drugs has failed to match this growth. By 2012, it’s expected that more than two billion people will be overweight and 600 million will be obese, representing immense opportunities for both the markets.

The market for weight loss drugs is characterized by numerous failures. A number of drugs have failed to get approval, some have been recalled, and those that have entered the market either suffer from serious side effects or have just failed to give the desired weight loss results consumers expected from them. Refusal of healthcare authorities to grant reimbursement to these drugs has also impeded the growth.

One of the most recent examples can be taken from Sanofi’s Acomplia; the drug was hailed as multibillion blockbuster before it was launched. But Acomplia, like most of its predecessors, failed to have a sufficient benefit to risk ratio and was taken off the market just two and a half years after its launch.

The future of the obesity drugs market, however, may not be so gloomy. This is because the market has high unmet demand, and any drug that manages to provide a high benefit to risk ratio can easily achieve blockbuster status. Moreover, despite some of its recent failures, the obesity drugs pipeline is rich and a large number of drugs are in phase-III and late phase-II trials. If some of these drugs manage to reach the market and posses a strong efficacy and safety profile, they can quickly become billion-dollar blockbusters.

Country-wise, the US is presently the biggest market for weight loss drugs with around 68% of its population either overweight or obese. The US is followed by the UK and other European countries. In future, emerging economies such as China, Russia, India and Brazil are also expected to become a huge market for weight loss products. With China’s obesity and overweight levels touching 665-670 million in 2015, the country will emerge as the most potential weight loss market.

Technorati Tags: health, weight loss

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Did you know that a little over 2 million Americans suffer from gout symptoms every year? If you want to reduce your chances of suffering from gout for too long, you’ll need to know the signs to look for so you can get immediate treatment and decrease the amount of time it takes for you to recover. After reading the following indicators of gout below, you’ll be equipped to more easily stave off the more debilitating aspects of this arthritic disease.

The first of several gout symptoms will more than likely creep up on you at night while you’re sleeping. You’ll wake up to swollen, shiny red skin pulled tightly over an inflamed joint. The big toe is usually the main culprit, but other joints can be affected too. Check your wrists, elbows, ankles, knees, and fingers.

Next, monitor the pain your joint to see if it becomes more painful over several hours. After a few hours have passed, you may not even be able to touch the joint without wincing due to the excruciating pain.

Sometimes gout symptoms can come in the form of feelings of extreme tiredness and a slight fever. If you feel chronically fatigued and listless in addition to having a painful and swollen joint, then you probably are suffering from gout. Also, take your temperature: 99.5 degrees Fahrenheit or higher in addition to that painful joint may signal gout too.

Running down the gout symptoms checklist again: do you have a shiny, red, swollen joint that warm and painful to the touch? Does the pain get progressively worse over the course of a few hours? In addition to the painful joint, do you have a slight fever or do you feel fatigued? If you experience these indicators, get treatment or try gout pain remedies as soon as possible.

You probably have something in your kitchen right now that can immediately relieve pain from any gout symptoms you have. Control and prevent current and future gout attacks naturally without medications, prescriptions, or untested remedies by visiting http://www.GetGoutRelief.com right now
 

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If your overweight, you may be experiencing back pain.

Traditional medical wisdom has long stated that the firmer the mattress, the better it’s for back pain sufferers.

Now, a Spanish scientific study- published in the prestigious British medical journal The Lancet on November 2003 - strongly suggests that traditional wisdom is wrong.

The study, conducted by Francisco Kovacs of Kovacs Foundation in Palma de Mallorca, has analyzed 313 people with cronic non-specific low back pain, that sleeped on mattresses with different levels of firmness.

After 90 days, the results showed that the medium-firm mattresses outscored the firmer ones by a significant margin, a definitive response and a definitive debunking of traditional wisdom.

But, more important, the study also showed that sleeping on a new mattress, whether it’s very firm or medium-firm, rather than an old one, was associated with more frequent discontinuation of drug treatment and relevant improvement in pain and disability. So, we have the scientific support that replacing an old mattress with a new one can improve back pain.

These results have been recently confirmed by a new, groundbreaking study “Subjective Rating of Perceived Back Pain, Stiffness and Sleep Quality Following Introduction of Medium-Firm Bedding System,” published in the Journal of Chiropractic Medicine (Winter 2006), authored by Bert Jacobson, EdD, Tia Wallace, MS, and Hugh Gemmell, DC, EdD of Oklahoma State University.

The study shows the critical link between mattress quality and sleep quality, as well as the importance of regular mattress replacement. In fact a new mattress, compared to a 5-7 years old ones, improves sleep quality by 62% and sleep comfort by 70.8%, plus reduced back pain by 55.3% and back stiffness by 50.7% over a four week period. The study has also found that lower back pain was much more prominent for people who sleep on cheaper beds and older beds.

So please, don’t let anyone tell you that sleeping through the night is a luxury: a good night’s sleep is essential to great health! Here are some number.

Recent statistics say 70 millions Americans are affected by sleep problems and the latest scientific researches suggest that our life could depend on sleeping well. Even minor sleep deficits rocket your production of stress hormones. Sleeping less than 6 hours can raise the risk of numerous health problems. Some examples?

An healthy night’s sleep can help your body: manage stress and maintain healthy blood sugar, because sleep deficits increase the levels of cortisol and other stress hormones, and this can have a negative impact on healthy blood sugar levels too; stay at a healthy weight because some studies show that adults who sleep the least appear to be the most likely to gain weight, because sleep deprivation increases levels of two critical hormones involved in regulating food intake - ghrelin and leptin - and this may lead to overeating and weight gain.

Now, we’ve scientific proofs that a new, high quality mattress leads to a good night’s sleep and this leads to an healthier and more productive life. The mattress should be one of the most important investment we ever make…don’t sleep on it!

Oliverio Abitrante - Materassi Sogni d’oro - http://www.materassisognidoro.it

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