I have Eczema!

As if things have not gotten more complicated already, now I’ve discovered that the itching I’ve been having for the last 2 years is Eczema.

It started off mild enough….once a month or so, there will be a slight itch that will go away after applying moisturizer for a couple of nights. Then last year, it was a little more sever, as I had gone on vacation in Italy, and the weather was too dry for me. The dry skin persisted on my hands, arms and legs, but it stopped after I applied some steroid cream from my doctor.

However, a few weeks later, the eczema flared up quite badly, such there there was sever itching. Within days, the dry skin had become leathery and red…..

I used steroid creams, despite knowing that it will thin the skin and bones…I was desperate. But it did not work….

steroid creams

I started to moisturize like crazy…….

I tried many different brands of moisturizers

I bought in bulk and stocked up!

After 6 months, spending a small fortune on creams, I stumbled on the eBook which helped me resolve my Eczema in 2 weeks!

Now I realize that Eczema is not a simple case of dry skin…the root cause lies in your immune system, your diet and understanding what you are eating, as well as how your body’s immune system works. Moisturizing your skin works on the dermis (upper skin layer), but not internally. Vitamins A and E are needed in your diet. On hindsight, I realized that I have neglected my health and diet due to my busy schedule. Since I followed the advice in the eBook, I have recoved from Eczema and have never felt healthier!

For Eczema suffers, don’t delay….visit the official website NOW!

You owe it to yourself to an itch-free life.

What Eczema looks like

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Findings from the Phase II SYNCHRONY study show that aleglitazar, a treatment for Type 2 diabetes, could be safe and effective and thus will be entered into Phase III trials. The data, already published online and forthcoming in The Lancet, were presented at the recent American Diabetes Association meeting in New Orleans, La.

Aleglitazar is in a class of drugs called PPAR coagonists, meaning it can affect both glucose and fat (lipid) control. It also shares functional similarities with the thiazolidinedione family of drugs, along with, for example, rosiglitazone and pioglitazone. Both rosiglitazone and pioglitazone are well documented as effective agents for blood glucose control in patients with Type 2 diabetes, but both also have a number of safety concerns attached to their use.

A number of PPAR coagonists developed so far have been discontinued owing to toxic effects.

Professor Robert R. Henry, University of California, San Diego, and colleagues—authors of SYNCHRONY—were hopeful that aleglitazar could have a similar positive effect on glucose control, but without the accompanying safety issues.

In the Phase II randomized study, patients with Type 2 diabetes (either drug-naïve or treated with two or fewer oral agents) were enrolled from 47 sites in seven countries. Following a five-week run in period with all patients on placebo, 332 were randomized to 16 weeks of treatment with aleglitazar at once-daily doses of 50, 150, 300, 600 µg, or matching placebo (55 in each group), or to pioglitazone 45 mg once daily (57 patients) as a reference. The primary endpoint was the change in glycosylated haemoglobin concentration (HbA1c) from baseline to the end of treatment.

The researchers found that aleglitazar reduced baseline HbA1c versus placebo in a dose-dependent manner, from -0.36 percent with 50 µg to -1.35 percent at 600 µg. The trend of changes over time suggested that the maximum effect of aleglitazar on HbA1c concentration was not yet reached after 16 weeks of treatment.

Source: EurekAlert! 6/8/09

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GlaxoSmithKline in February announced initiation and dosing of the first patient of the Phase III clinical trial programme to evaluate the efficacy, safety, and tolerability of the investigational GLP-1 (Glucagon-like peptide 1) agonist Syncria® (albiglutide) in men and women with type 2 diabetes.

The Phase III program will include more than 4,000 patients and will begin with five studies in early 2009. The objective of the program is to demonstrate durable efficacy and cardiovascular safety of albiglutide as mono- and add-on therapy. The primary efficacy endpoint for all studies will be the change from baseline in HbA1c compared to placebo and/or active comparators. A majority of the studies will include active comparators, including metformin, sulphonylurea, thiazolidinedione (TZD) insulin, and a dipeptidyl peptidase four inhibitor (DPP IV). The study duration is expected to be two to three years and the main dose and regimen for the programme will be 30 mg weekly.

Albiglutide is an investigational biological, injectable form of human GLP-1–a peptide that acts throughout the body to help maintain normal blood-sugar levels and to control appetite. In people with type 2 diabetes, GLP-1 secretion in response to a meal is reduced.

Albiglutide is the only medication that fuses human GLP-1 to human albumin. It is designed to have an extended duration of action and allow for weekly or less-frequent injections.

Source: PRNewswire 2/17/09

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I know that many chronic obese people rely on Weight loss drugs to control their weight. No doubt despite the side effects, some people have really tried everything to natuarally lose weight, but to no avail. With a doctor’s advice, they resort to medication. These naturally come with side effects, and sometimes are not even effective in the long term. Hence, we find many studies on going to find better drugs with fewer side effects….here’s the latest.

Corcept Therapeutics in February announced additional positive results from a clinical study that tested whether Corlux® mitigates the weight gain and other metabolic effects associated with Risperdal®. The company previously announced top-line data demonstrating that adding Corlux to Risperdal treatment in healthy subjects resulted in a statistically significant reduction in weight gain compared to that seen in subjects receiving Risperdal alone.

Analysis of key secondary endpoints demonstrates that the addition of Corlux to Risperdal also results in less abdominal fat, lower fasting insulin levels, and lower triglyceride levels–all of which were statistically significant compared to treatment with Risperdal alone. Risperdal, a leading antipsychotic for the treatment of schizophrenia and bipolar disorder, is marketed by Johnson & Johnson.

Corlux is Corcept’s late-stage GR-II receptor antagonist, which the company is also evaluating in ongoing Phase III trials for psychotic depression and Cushing’s Syndrome. The results from this study confirmed results previously reported from a similar clinical study of Corlux when added to treatment with Zyprexa, which demonstrated statistically significant mitigation of Zyprexa-associated weight gain, as well as a favorable impact on metabolic markers.

The new study was a four-week randomized double-blind controlled trial in 75 lean, healthy men (body mass index of 23 or less). Subjects were randomized to receive either Risperdal plus placebo (n=30), Risperdal plus Corlux (n=30), or Corlux plus placebo (n=15).

Daily weights were recorded, as well as abdominal fat (as measured by waist circumference), fasting insulin, and triglycerides. Subjects in the Risperdal alone group gained an average of 9.2 pounds, compared to a gain of 5.1 pounds in the Risperdal plus Corlux group. The increase in abdominal fat was 3.57 cm in the Risperdal alone group, compared to 2.03 cm in the Risperdal plus Corlux group. Fasting insulin increased by 10.97 mU/L in the Risperdal alone group, compared to 1.80 mU/L in the Risperdal plus Corlux group. In addition, triglycerides increased by 30.57 mg/dL in the Risperdal alone group, compared to an increase of only 3.13 mg/dL in the Risperdal plus Corlux group.

Source: Marketwire 2/23/09

Technorati Tags: health, weight loss

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FDA Warns Consumers Against Dietary Supplement Containing Undeclared Drug
Product poses safety risk

The U.S. Food and Drug Administration is warning consumers not to take Venom HYPERDRIVE 3.0, a product sold as a dietary supplement and containing sibutramine. Sibutramine, a controlled substance with risks for abuse or addiction, is a potent drug that poses potential safety risks.

“Sibutramine is the active ingredient in an FDA-approved prescription drug used as an appetite suppressant for weight loss,” said Janet Woodcock, M.D., director of the FDA’s Center for Drug Evaluation and Research. “But when present in a dietary supplement, it may harm unsuspecting consumers because sibutramine can substantially increase blood pressure and heart rate (pulse), and may present a significant risk for people with a history of heart disease, heart failure, irregular heart beats or stroke.”

Venom HYPERDRIVE 3.0 is marketed by Applied Lifescience Research Industries Inc. (ALR Industries), Oak View, Calif. On Dec. 24, 2008, ALR Industries initiated a recall of all lots of Venom HYPERDRIVE 3.0 after the FDA laboratory analysis showed samples of the product contained undeclared sibutramine. Although ALR Industries claims on its Web site that only “trace amounts” of sibutramine were found in this product, the FDA laboratory tests showed that Venom HYPERDRIVE 3.0 contains a significant amount of sibutramine per dosage unit.

The product was sold via distributors and in retail stores nationwide as well as in Canada, Poland, Sweden, Hungary, South Africa, the Netherlands, Australia, France and the United Kingdom. The product was packaged in red plastic bottles containing 90 capsules each with the UPC# 094922534743.

Consumers who have this product should stop taking it immediately and contact their health care professional if they have experienced any adverse effects. Consumers can contact the company at legal@alrindustries.com to receive further instructions for returning the product and to ask any questions.

Health care professionals and consumers may report serious adverse events (side effects) or product quality problems with the use of this product to the FDA’s MedWatch Adverse Event Reporting program either online, by regular mail, fax or phone.

• Online
• Regular Mail: use postage-paid FDA form 3500 and mail to MedWatch, 5600 Fishers Lane, Rockville, MD 20852-9787
• Fax: (800) FDA-0178
• Phone: (800) FDA-1088

For an updated list of all tainted weight loss products, go to: http://www.fda.gov/bbs/topics/NEWS/2008/NEW01933.html.

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Technorati Tags: diet, health, weight loss

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